With the Fantastic Four title performing well, Lee and Kirby were trying to dream up a "soul-stirring…super sensational new villain" for the series. Like many of Marvel's Silver Age characters, Doom was conceived by Stan Lee and Jack Kirby. Publication history ĭoctor Doom's debut in The Fantastic Four #5. Most notably, Doctor Doom has been portrayed in licensed Fantastic Four live-action feature films by Joseph Culp in Roger Corman's unreleased 1994 film Julian McMahon in the 2005 film and its 2007 sequel and Toby Kebbell in the 2015 film. The character has been substantially adapted from the comics into several forms of media, including television series, video games, and merchandise such as action figures and trading cards. In a later article, IGN would declare Doom as Marvel's greatest villain. He has also been portrayed as an antihero at times, working with the heroes if their goals align and only if it benefits him.ĭoctor Doom was ranked #4 by Wizard on its list of the 101 Greatest Villains of All Time and #3 on IGN's list of the Top 100 Comic Book Villains of All Time. He has also come into conflict with other superheroes in the Marvel Universe, including Spider-Man, Iron Man, Doctor Strange, Black Panther, the X-Men, and the Avengers. The monarch of the fictional nation of Latveria, Doom primarily serves as the archenemy of Reed Richards and the Fantastic Four. Created by Stan Lee and Jack Kirby, the character first appeared in The Fantastic Four #5 (July 1962). Victor Von Doom) is a supervillain appearing in American comic books published by Marvel Comics. Romani camp outside Hassenstadt, Latveriaĭoctor Doom ( Dr. Doctor Doom, on the variant cover of The Amazing Spider-Man vol.
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Can't wait to see their bright future □□Īnd it is a so powerful picture as it is depicting 2 symbols:-ġ) Ind is a country where Spirituality reaches Science.Ģ) Bindi & long black hairs are the major part of Indian women.Īpprobate NASA for proudly showing it □. Great to see that Goddess Saraswati has blessed them with knowledge. They can hold both the masks together seamlessly. And when it suits them they can go back to their tradition, their caste etc. So, when it suits them they can act completely modern. Pic 4: Hindus have the ability to behave in a very instrumental way. Ethan Miller/Getty Images A woman whose expletive-ridden tweet may have cost her a Nasa internship could get it back. There were many people who came out in her support too and she received a wave of support from India. However, some people mocked the photo of the Indian-origin girl for having Hindu idols next to her laptop in the photo for equating religion with science. Today's the day: applications for fall NASA internships are due!Īre you ready? Visit and apply at: /CVwFJGYbms The post on Twitter showed photos of four diverse interns and was simply captioned, “Today’s the day: applications for fall NASA internships are due!” USA’s top space agency, NASA had posted a tweet with four photos as a reminder for its fall applications for internships. If a student is rejected they can reapply for the program.NASA’s attempt to showcase diversity backfired after an Indian-origin intern was mocked for posing with Hindu idols in a photo. Interns do receive a manual that includes expectations regarding use of social media. Privacy regulations prohibit the agency from discussing specific details. The Universities Space Research Association has responsibility for administering the internship program but does confer with NASA regarding its selection decisions. While they couldn't comment on this specific incident, they did tell us that interns receive a manual which includes guidelines on how to behave on social media: I think I might get my internship again thank you all for the supportĪ spokesperson for the NASA Johnson Space Center informed us that the Universities Space Research Association is responsible for administrating the internship program. The Twitter account purportedly Naomi's new account, posted a message on 23 August 2018 expressing hope that she might get her internship back: It's unclear if Hickam was successful in getting Naomi a position at NASA. I have also talked to the folks that had to do with her internship and made absolutely certain that there will be no black mark on her record. After talking to her, I am certain she deserves a position in the aerospace industry and I'm doing all I can to secure her one that will be better than she lost. She reached out to me with an unnecessary apology which I heartily accepted and returned with my own. As it turned out, it was due to the NASA hashtag her friends used that called the agency's attention to it long after my comments were gone. This I had nothing to do with nor could I since I do not hire and fire at the agency or have any say on employment whatsoever. Later, I learned she had lost her offer for an internship with NASA. Soon, her friends took umbrage and said a lot of unkind things but long after I was gone as I immediately deleted my comments and blocked all concerned. However, when I saw NASA and the word used together, it occurred to me that this young person might get in trouble if NASA saw it so I tweeted to her one word: "Language" and intended to leave it at that. I'm a Vietnam vet and not at all offended by the F-word. Recently, it was called to my attention on Twitter that someone was being hired by NASA and that they were using the F-word in a tweet about it. Hickam's post is reproduced in full below: Monica learned about the heat capacity and assembly of tiles on a shuttle, the NASA Neutral Buoyancy Lab, and the women who have ventured to space. As she watched, her interest in space grew. Hickam explained in the since-deleted blog post (an archived version can be seen here) that he didn't mean to get Naomi in trouble when he responded to her tweet, and that he has since reached out to NASA on her behalf. ‘As a four-year-old, Monica Saraf repeatedly played the ‘Big Space Shuttle’ DVD that her parents had gifted her. Hickam, a former NASA engineer whose 1998 memoir Rocket Boys served as the basis for the movie October Sky, confirmed that the exchange was real on his web site. So was this exchange real? Did Naomi really lose her internship after insulting a member of the National Space Council? Hickam and Naomi have declined requests for comment from the media. These tweets, as well as the Twitter handle were deleted shortly after this exchange went viral, but a number of news outlets managed to archive them via screenshots. For a would-be novelist struggling under my own debilitating anxiety of influence, no more valuable lesson existed. It didn’t matter that McCarthy’s literary models were obvious, because he wrote as well as they did and occasionally better. But although I registered the novel’s considerable stylistic debts both to Hemingway and Faulkner - not to mention “A Portrait of the Artist as a Young Man” - I was so intoxicated by its music that the point seemed academic. Part of what makes it so memorable, of course, is its odd, self-consciously archaic cadence - the oft-cited ‘biblical’ loftiness of McCarthy’s prose, which may be one reason few writers of my generation care to cite him as an influence. That line has lost none of its mystery, its austerity, its elegant foreboding. What neither of us imagined was that the glossy trade paperback with its attractively minimalist black-and-white cover would act as the catalyst for my entire professional life. I’d recently lost both my job and my apartment, and a friend thought a book about cowboys might distract me from my woes. When McCarthy’s sixth novel swept into my life, I was 24 years old and living in a tent I’d pitched in the basement of a warehouse under the Manhattan Bridge. I might never have finished a book if not for “ All the Pretty Horses” - and I don’t mean this in some vague or sentimental sense. The omission wasn’t due to any lack of impact on my writing, that’s for certain. Le Guin - even, just a few weeks ago, whoever ghost-wrote David Lee Roth’s memoir, “Crazy From the Heat.” But one name I’ve conspicuously avoided all these years has been that of McCarthy, who died last week at 89. Burroughs, Amos Tutuola, Lydia Davis, Toni Morrison, John Berger, Ursula K. In the two decades since my first book was published, I’ve fielded the boilerplate question about my influences no end of times, name-checking an almost absurdly ragtag crew: Shirley Hazzard, Denis Johnson, William S. In spite of the enormity of his shadow, however, I’ve never before written about the author of so many novels I’ve studied and admired. But virtually all of us, whatever our position or attitude, existed in its shade. Some of the novelists of my generation found the mountain beautiful others found it oppressive. For the entirety of my writing life, Cormac McCarthy has been a mountain. Genetic impairment of AMPKα2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice. Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. Role of AMPKα2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle. Muscle hypertrophy in prediabetic men after 16 wk of resistance training. Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Isoform-specific and exercise intensity-dependent activation of 5’-AMP-activated protein kinase in human skeletal muscle. Plasma catecholamines and essential hypertension. Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. Exercise, GLUT4, and skeletal muscle glucose uptake. The role of CaMKII in regulating GLUT4 expression in skeletal muscle. This was the first study to quantify CaMKII activation in human skeletal muscle in response to exercise. Exercise increases Ca 2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals. AMPK: an energy-sensing pathway with multiple inputs and outputs. This study uncovered the exercise intensity-dependent activation of AMPK in human skeletal muscle. Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. Skeletal muscle hypertrophy after aerobic exercise training. Physiological basis of brief vigorous exercise to improve health. Concurrent exercise training: do opposites distract? J. Molecular mechanisms of muscle plasticity with exercise. Training for endurance and strength: lessons from cell signaling. T.) (American Physiological Society, 1996). Exercise: Regulation and Integration of Multiple Systems (eds Rowell, L. Exercise metabolism in 2016: health benefits of exercise - more than meets the eye! Nat. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Lack of exercise is a major cause of chronic diseases. The possibility of designing therapeutic interventions based on these molecular mechanisms is addressed, using relevant examples that have exploited this approach.īooth, F. This Review provides an overview of the beneficial adaptive responses to exercise and details the molecular mechanisms involved. With this knowledge also comes the opportunity to design new therapeutic strategies based on the biology of exercise for a variety of chronic conditions where regular exercise might be a challenge. Our understanding of the epigenetic and transcriptional mechanisms that mediate the skeletal muscle gene expression response to exercise as well as of their upstream signalling pathways has advanced substantially in the past 10 years. This adaptive response increases oxidative capacity and influences the function of myokines and extracellular vesicles that signal to other tissues. The phenotypic alterations observed in skeletal muscle are partly mediated by transcriptional responses that occur following each individual bout of exercise. It is well appreciated that regular exercise improves metabolism and the metabolic phenotype in a number of tissues. Exercise is fundamental for good health, whereas physical inactivity underpins many chronic diseases of modern society. 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Click the - select value - cell in the Column section, and select gal80Rexp in the drop-down.Find Fill Color in the list of Node properties and expand it to view the mapping options.Click on the Style tab in the Control Panel.Significance of expression values, gal80Rsig, will be mapped to Node Border Width nodes with significant changes will appear with a thicker border.The gal80Rexp expression values will be mapped to Node Fill Color nodes with low expression will be colored blue, nodes with high expression will be colored red.We can now use the data to manipulate the visual properties of the network by mapping specific data columns to visual style properties: To learn more about importing data, see the Importing Data From Tables. Similarly, you can select one or more rows in the Node Table, right-click on the selected rows and click Select nodes from selected rows to highlight the corresponding nodes in the network.Selecting nodes in the network (Shift + Click or Click-and-Drag) will update the Node Table to show only data for those nodes.The data used in this example is from yeast, and represents an experiment of perturbations of the genes Gal1, Gal4, and Gal80, which are all yeast transcription factors.įor this tutorial, the experimental data was part of the Cytoscape network file you loaded earlier, and is visible in the Node Table: Here, we will show an example of doing this. This creates a powerful visualization, portraying functional relation and experimental response at the same time. Probably the most common use of expression data in Cytoscape is to set the visual properties of the nodes (color, shape, border) in a network according to expression data. To learn more about importing networks from local files, see the Loading Networks Tutorial. The network will open with the default style, similar to the network on the right:.Click the Import network to Cytoscape (green arrow) button to the left of the network name. In the search results, find the galFiltered network with data.In the Network Search interface in the Control Panel, select NDEx from the drop-down, and type in "GAL1 GAL4 GAL80". We will use NDEx to find a relevant network.To get started, install and launch the latest version of Cytoscape. So The Tanka above falls into this classification. CinquainĪt its very base, this is simply a 5 line poem. So it’s a Haiku with 2 seven-syllable lines added to the end. Related in a sense to the Haiku, the Tanka poem is a poem with 5,7,5,7,7 for its lines. This verse from the Jungle Book is a good example of a limerick. Limerick is, at its core (giving the basic definition here) a 5 line poem that follows a strict meter and always has a AABBA rhyme scheme. In the Beginning how the Heav’ns and Earthĭelight thee more, and _Siloa’s_ Brook that flow’dįast by the Oracle of God I thence Limerick That Shepherd, who first taught the chosen Seed, Sing Heav’nly Muse, that on the secret top Restore us, and regain the blissful Seat, With loss of _Eden_, till one greater Man Of that Forbidden Tree, whose mortal tasteīrought Death into the World, and all our woe, Of Mans First Disobedience, and the Fruit Milton wrote his masterpiece Paradice Lost in blank verse: It can follow another meter, but Iambic pentameter is the most common by far. Blank Verseīlank Verse is a poem written in Iambic pentameter but does not rhyme. There are more kinds of sonnets, like the Miltonic and modern ones, but the three above are what people talk about when they say the word sonnet. What trophee then shall I most fit deuize, Of their great deeds and valarous emprize. In which they would the records haue enrold, The famous warriors of the antique world, Named after famous poet Edmund Spenser this poem has three interlocked quatrains and a final couplet, with ABAB BCBC CDCD EE as its rhyme scheme. So long lives this, and this gives life to thee. So long as men can breathe or eyes can see, When in eternal lines to time thou grow’st. Nor shall Death brag thou wanderest in his shade, Nor lose possession of that fair thou ow’st, Sometimes too hot, the eye of heaven shines,Īnd every fair from fair sometime declines,īy chance or nature’s changing course untrimmed. Rough winds do shake the darling buds of May,Īnd summer’s lease hath all too short a date. It’s generally more complicated than it sounds. It is a 14-line poem written in iambic pentameter. Popularized by William Shakespeare, this is the most famous type of poem. In his first splendour, valley, rock, or hill Īnd all that mighty heart is lying still! Shakespearean Ships, towers, domes, theatres, and temples lieĪll bright and glittering in the smokeless air. William WordsworthEarth has not anything to show more fair:ĭull would he be of soul who could pass by An excellent example of this type of sonnet is:Ĭomposed Upon Westminster Bridge, September 3, 1802 Poets study their whole lives to perfect writing these types of sonnets. The poem is made up of an Octave (an 8 line stanza ABBAABBA.) and a sestet (a 6 line stanza CDECDE or CDCDCD). It is generally written in iambic pentameter if written in English. Named after Francesco Petrarca, it is sometimes called the Italian sonnet. The English sonnet is the most attempted. There is also the Italian or Petrarchan sonnet. Of course, there is much more to these, but this is the general definition. There are various sonnets, but the most popular ones tend to be the English or Shakespearean sonnets. It’s 3 line poem generally where the first and last lines have five syllables, and the middle has seven. Poets like Matsuo Bashō, Yosa Buson, and Natsume Sōseki are renowned for their Haiku. Haiku is the only poem that rivals free verse these days. It is undoubtedly the most common form used today. A form we think of when we write a poem not based on any patterns or structure. Refrain from being mixed up with blank verse free verse is a poetic form/technique where the poet does not follow the conventions of any meter or rhyme. Please try each type, and if you do, feel free to share them in the comments. If someone throws these at you, at least you will know what they are. I wanted to develop a short list of the most famous poetry types. These are poems where people use a particular form to create them, but some are forms in and of themselves. I say forms or formats because we cross some lines of distinction here that are only sometimes easy to explain. Here is a list of the Top 10 Types of Poems, Forms, or Formats. The Christmas Tree Festival encourages entrants to get creative and you. Discover Fair Foodie Fest Winter Wonderland Angel Stadium, with free admission plus takeout holiday fair food, carnival games from your car, and even a socially distanced santa photo opp all. This treasure trove of curiosities is a perfect location to meet up with friends while enjoying foodie delights from The Harley Caf. Budapest is transformed into a winter wonderland with several Christmas markets. Its the time of year when Kilkenny becomes a winter wonderland and it is not to. Somehow, this place had vendors mess up cheese fries.like how The fries were. The festival features classical music concerts, theater performances. Welcoming 160 vendors, you can get in the festive spirit with gifts from local artists, craftsmen and entrepreneurs. The food was very basic, over priced fair food.of course, some fair food is delicious. In sixth place is the Union Square Holiday Market in New York.įrom mid-November to Christmas Day the market attracts thousands of visitors from all around the world. Keep the kids entertained in the Alpine Activity Area with free craft workshops, family fun DJs (come ready with your song requests), dance classes, an Amazing. The market's new addition this year is the the Winter Hütte, which offers a ‘Swiss with a Twist’ dining experience from one of Yorkshire’s best-known chefs, the Michelin-starred Andrew Pern. It's York Christmas Market that makes the list however, due in no small part to the obscenely idyllic and picturesque atmosphere created by buying a ginger bread man on the city's winding and cobbled streets, magnificent minster towering overhead. In fifth place is another from the UK's now excellent Christmas market scene, which proudly supports big hitters such as Birmingham Frankfurt and Nottingham's. During the time you'll be able to pick up festive goods from a vast array of stalls and say hello to the on-site reindeer. The top seven players at the position have all been contributors for the team at various times, as Green Bay returns all five members of its preferred offensive line. It shouldn’t have been a surprise that the Packers didn’t draft one this year. Going into the 2023 draft, I thought the offensive line was a position that warranted either a big swing (for a left tackle of the future) or the team passing up on the position entirely. Tyler Davis will likely continue his contributions on special teams and as a rotational inline and wing tight end to give heavy contributors some breathers. Josiah Deguara should remain a hybrid wing and fullback type of player for the team. Tucker Kraft, a fourth-round pick, is ideally an inline tight end who can also play on the wing. Luke Musgrave, the team’s second-round pick, is going to be a mismatch player who has the potential to play as an inline tight end. The double dip at tight end on Day 2 of the draft has cleared up the tight end position very nicely. I would guess that the final spot at the position is going to come down to either DuBose or Bo Melton, the 2022 draft pick who the Packers took off of the Seattle Seahawks’ practice squad in December. On top of that, the Packers just drafted Jayden Reed (second round), Dontayvion Wicks (fifth round) and Grant BuBose (seventh round) in the 2023 draft. The dark horse here is Tyler Goodson, a 2022 preseason darling who spent the entirety of his rookie campaign on the practice squad.Ĭhristian Watson and Romeo Doubs put up quality production as rookies last season and the team seems to like Samori Toure enough to keep him on the squad this year, too. Patrick Taylor took over the role as the team’s third back once Hill was out of the picture, but the team often called him up off the practice squad to fill that spot. 2021 seventh-round pick Kylin Hill was supposed to be that player, but was released by the squad in 2022 almost as soon as he was medically cleared to return from his 2021 ACL tear. The Packers just drafted Lew Nichols III out of Central Michigan in the seventh round, who could stabilize the depth of the position for the first time since Jamaal Williams left in free agency. The third running back job is going to be a camp battle, though. For a point of reference, Jack Haener, Stetson Bennett, Aidan O’Connell, Clayton Tune and Dorian Thompson-Robinson were all drafted at the position in a 14-pick run.Īaron Jones and AJ Dillon are locks to make the 2023 team, barring some unforeseen trade of Dillon’s expiring contract. As general manager Brian Gutekunst put it, a run of quarterbacks they liked less than Clifford occurred just before Clifford’s selection. While Sean Clifford wasn’t expected to be drafted, according to consensus draft boards, Green Bay’s staff reiterated multiple times on Saturday that they were unsure if he was going to be available at their selection. Jordan Love is the quarterback of the future and there’s a very low chance that the Packers would release a fifth-round rookie quarterback, considering the alternative right now in the backup role is Danny Etling. They’ll be in depth chart form, outside of the offensive line (left to right.) There are a few spots that are too close to call, but we’ll mention who is in contention for those battles in our notes. We’ll take you through a position-by-position breakdown of the Packers’ roster as we make our choices for Green Bay’s 53-man roster. With that being said, there are going to be some highly-contested battles in camp - notably on the offensive line and in the secondary. After turning in 13 draft picks, it’s clearer which players are going to make general manager Brian Gutekunst’s squad. Now that the 2023 draft is over, the Green Bay Packers’ roster has taken a much more firm shape than it was in a few days ago. |
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